TCR-Antigen mapping for COVID—19 to identify the immune response signature the key cells

The key cells of the adaptive immune system that enable the body to mount responses against antigens—T cells and B cells. T cells and B cells randomly assemble different gene segments–called variable (V), diversity (D) and joining (J) genes–in a process called VDJ recombination, designed to generate antigen receptors that can collectively recognise molecules posing exogenous or endogenous threats to the body. OBJECTIVE Use of antigen-mapping technologies to determine all possible T-cell receptors that bind to clinically relevant antigens across diseases. AIM To generate immune response data of Immune cell receptors from the blood samples of patients diagnosed with or recovering from COVID-19. METHODOLOGY 1. ImmunoSEQ is designed to sequence single chains of “Y-shaped” T cell receptors or B cell receptors using next-generation sequencing (NGS). 2. MIRA (Multiplexed Identification of T cell Receptor Antigen Specificity) — MIRA maps millions of TCRs to thousands of clinically relevant antigens. Monday, 13 April 2020 HARINI RAJEEV 2 DISCUSSION Mapping immune receptor sequence to SARS-CoV-2-specific antigens will help in identifying “The immune response signature”. The relevant receptor sequence might be very, very potent, but very, very infrequent. So, large scale sampling is the need of the hour. Sampling millions of T cell and B cell repertoires, could help identify which receptor sequences are specific to which antigens. And then use that to either diagnose or to treat disease.

SHARE HOLDERS Adaptive Bio’s proprietary immune medicine platform— agreed to spend $12 million over 7year period. Microsoft Azure® cloud computing platform —- $45M Investment Adaptive Biotechnologies Corporation Notes to Unaudited Condensed Financial Statements March 31, 2019

STAKE HOLDERS The underwriters expect to deliver the shares against payment in New York, New York on 2019. Monday, 13 April 2020Goldman Sachs & Co. LLCJ.P. MorganBofA Merrill LynchCowenGuggenheim Securitie sJames Evans Robert Freedman Amanda Rose Fenwick & West LLP 1191 Second Avenue, Floor 10 Seattle, Washington 98101 (206) 389-4510